Aromatic Oligoamide Foldamers with a “Wet Edge” as Inhibitors of the α‐Helix‐Mediated p53–<i>h</i>DM2 Protein–Protein Interaction

Abstract

Abstract This paper describes the design, synthesis and structural analysis of a 3‐ O ‐alkylated aromatic oligoamide that incorporates an additional hydrophilic 6‐ O ‐alkyl substituent in the central monomer. This oligomer exhibits low μ M inhibitory potency against the p53– h DM2 interaction compared with its unfunctionalised counterpart and significantly improved solubility.