Increased Locomotor Activity Induced by Heroin in Mice: Pharmacokinetic Demonstration of Heroin Acting as a Prodrug for the Mediator 6-Monoacetylmorphine in Vivo

Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection

William H. Oldendorf, Susan Hyman, Leon D. Braun et al. · Science · 1972 · 361 citations

Medicine, Neuroscience, Pharmacology +17

The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat

Eileen M. Joyce, Susan D. Iversen · Neuroscience Letters · 1979 · 355 citations

Life Sciences, Neuroscience, Pharmacology +14

Retention of heroin and morphine–6β–glucuronide analgesia in a new line of mice lacking exon 1 of MOR–1

Alwin G. Schuller, Michael A. King, Jiwen Zhang et al. · Nature Neuroscience · 1999 · 306 citations

Nursing, Neuroscience, Pharmacology +13

The Pharmacokinetics of Heroin in Patients with Chronic Pain

Charles E. Inturrisi, Mitchell B. Max, Kathleen M. Foley et al. · New England Journal of Medicine · 1984 · 243 citations

Medicine, Pharmacokinetics, Pharmacology +12

Evidence from opiate binding studies that heroin acts through its metabolites

Charles E. Inturrisi, Michael Schultz, Sang J. Shin et al. · Life Sciences · 1983 · 213 citations

Medicine, Medicinal Chemistry, Pharmacology +11