Intracellular Dyssynchrony of Diastolic Cytosolic [Ca ²⁺ ] Decay in Ventricular Cardiomyocytes in Cardiac Remodeling and Human Heart Failure

Abstract

In cardiomyocytes, cytosolic [Ca²⁺] decay is regulated locally and related to local sarcomere relengthening. Dyssynchronous intracellular [Ca²⁺] decay in cardiac remodeling and end-stage heart failure suggests a novel mechanism of cellular contractile dysfunction.