Solid‐Phase Library Synthesis of Polyynes Similar to Natural Products

Abstract

High in polyunsaturates: The combinatorial synthesis of a 65-membered polyyne library has been achieved by using an iterative acetylene homologation strategy combined with a solid support (see scheme). The library was evaluated against cancer cells to demonstrate its possible utility as a chemical tool to unravel cellular processes or as a platform for drug discovery and design. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z703208_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.