Sulbactam kinetics and excretion into breast milk in postpartum women

Abstract

We gave intravenous infusions of sulbactam, a beta-lactamase inhibitor, in combination with ampicillin or cephalothin to women 2 days after cesarean section delivery. The elimination t1/2 was 1.0 hours, the volume of distribution at steady state was 268 ml/kg, and renal clearance was 295 ml/min. These values are similar to those in normal young men and in surgical patients and suggest that dose regimens of sulbactam will not need adjustment in the postpartum period. Sulbactam concentrations in breast milk averaged 0.5 micrograms/ml, a value similar to that of several beta-lactam antibiotics.