Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma

Abstract

MFAP4 promoted the development of asthmatic airway disease in vivo and pro-asthmatic functions of bronchial smooth muscle cells in vitro. Collectively, our results identify MFAP4 as a novel contributor to experimental asthma, acting through modulation of airway smooth muscle cells.