PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[¹¹C]O-methylreboxetine and HRRT

Abstract

Our results suggest that (a) brain NET concentration declines with age in HC, and (b) there is a significant upregulation of NET in thalamus and dorsomedial thalamic nucleus in COC as compared to HC. Our results also suggest that the use of [(11)C]MRB and HRRT provides an effective strategy for studying alterations of the NET system in humans.