Human ocular melanocytes and retinal pigment epithelial cells differ in their melanogenic properties<i>in vivo</i>and<i>in vitro</i>

Abstract

The data suggest that normal human ocular melanocytes retain the capacity to produce pigment throughout adult life, and this can be demonstrated both ex vivo and in vitro. In contrast, we were unable to confirm that the majority of RPE cells play any significant role in active pigment production in the adult.