Alcohol and Alcoholism · 1996 · 36 citations · 13 references
MedicineMaternal HealthObstetricsMaternal-fetal MedicinePrenatal DiagnosisReproductive EndocrinologyAntenatal AssessmentFetal Alcohol Spectrum DisordersPregnancyPregnancy DiagnosisPregnancy EndocrinologyPrenatal AssessmentAlcohol Use During PregnancyAlcohol Use In PregnancyCarbohydrate-deficient TransferrinDiagnostic Testing AccuracyLinear RegressionMaternal Alcohol UseMultiple RegressionTransferrin Deficiency
Controversy exists whether carbohydrate-deficient transferrin (CDT) is valuable as a screening tool for fetal alcohol syndrome. We evaluated serum CDT in 60 non-alcohol-abusing women at different stages of normal pregnancy. CDT was weakly related to week of pregnancy and to human placental lactogen. CDT did not correlate with iron oestradiol or progesterone. By contrast, good correlations were found between transferrin and week of pregnancy or either sex hormone. Using multiple linear regression analysis, only transferrin and week of pregnancy were important predictors of CDT. The diagnostic accuracy of CDT for detecting alcohol abuse may be limited in pregnant women and should be carefully assessed in relation to alcohol consumption.
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Helge Bell, Chantal Tallaksen, K. Try et al. · Alcoholism Clinical and Experimental Research · 1994 · 120 citations