Matrix metalloproteinase‐1 and ‐3 gene promoter polymorphisms in Japanese patients with periodontitis

Abstract

Our data did not support the hypothesis that MMP-1 and/or MMP-3 gene promoter polymorphisms influenced the susceptibility to periodontitis in Japanese patients, indicating MMP-1 and MMP-3 expressions were regulated by complex processes such as cytokine network in periodontal disease rather than gene polymorphisms.