Concepedia

Incorporation of thioamide linkages into a growing peptide under SPPS conditions improved by salt effects

Hoang‐Thanh Le, Michel Mayer, Sylviane Thoret, R. Michelot

International journal of peptide & protein research · 1995 · 13 citations · 22 references

DOI

Concepts

Abstract

Amino acid methyl dithioesters may be coupled in the presence of DMAP and salts to a growing peptide chain on a polymeric resin with high coupling yields and low racemization.

References

22

Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides

E. T. Kaiser, Robert L. Colescott, C.D. Bossinger et al. · Analytical Biochemistry · 1970 · 3.5K citations

, , +10

Determination ofD-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene

Peter S. Marfey · Carlsberg Research Communications · 1984 · 1.4K citations · Full text

, , +7

Reinvestigation of the mixed carbonic anhydride method of peptide synthesis

George W. Anderson, Joan E. Zimmerman, Francis M. Callahan · Journal of the American Chemical Society · 1967 · 410 citations

, , +5

The monitoring of reactions in solid-phase peptide synthesis with picric acid

B. F. Gisin · Analytica Chimica Acta · 1972 · 352 citations

, , +8

Application of marfey's reagent in racemization studies of amino acids and peptides

Gyula Szókán, Gábor Mező, Ferenc Hudecz · Journal of Chromatography A · 1988 · 103 citations

, , +6