Serum concentrations of Anti‐Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism

Abstract

AMH secretion in patients with 47,XXY KS was within normal limits during mini-puberty and until puberty. Thereafter, AMH declined to subnormal levels in all patients. We hypothesize that this decline was a result of the hyalinization of seminiferous tubules in relation to puberty, rather than caused by disrupted regulatory mechanisms at the level of the pituitary-gonadal axis.