Recent Developments in Non‐Mercurial Diuretics

Abstract

Abstract Mercurial diuretics today are still the drugs of choice when a prompt and full diuretic response is needed. However, most mercurial diuretics are effective only when given parenterally. This factor, plus the toxicity usually associated with organic mercurials; has prompted the search for non‐toxic, orally active, non‐mercurial diuretic drugs. The most important group of organic compounds found to date which fulfills these conditions is the sulfonamides. Among these, derivatives of chlorothiazide and hydrochlorothiazide are most effective. In the following report these compounds are described in detail. Aldosterone antagonists and blockers of aldosterone excretion play only a minor role.