Randomized Trial of 2‐Dose versus Monthly Sulfadoxine‐Pyrimethamine Intermittent Preventive Treatment for Malaria in HIV‐Positive and HIV‐Negative Pregnant Women in Malawi

Abstract

In HIV-positive pregnant women, monthly SP IPTp is more efficacious than a 2-dose regimen in preventing placental malaria. The study also demonstrates the continued efficacy of SP for the prevention of placental malaria, even in the face of its decreasing efficacy for the treatment of malaria in children. In areas with intense transmission of falciparum malaria and a high prevalence of HIV infection, monthly SP IPTp should be adopted.