A Structural and Functional Model for Dioxygenases with a 2‐His‐1‐carboxylate Triad

Abstract

An attractive model: The iron complex shown on the left models the 2-His-1-carboxylate active sites of Rieske dioxygenases both in terms of structure and function. 18O-labeling studies of olefin dihydroxylation support the involvement of a high-valent iron-oxo species.