Mimicking Fructose and Rhamnulose Aldolases: Organocatalytic <i>syn</i>‐Aldol Reactions with Unprotected Dihydroxyacetone

Abstract

Completing the quattuorvirate: Amino acids that contain primary amines directly catalyze syn-selective asymmetric aldol reactions between unprotected dihydroxyacetone and a variety of aromatic and aliphatic aldehydes (see scheme). This new strategy provides the organocatalytic mimics of the L-rhamnulose 1-phosphate and D-fructose 1,6-diphosphate aldolases. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701269_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.