A Candidate Type 2 Diabetes Polymorphism Near the <i>HHEX</i> Locus Affects Acute Glucose-Stimulated Insulin Release in European Populations

Abstract

A common genetic variation in the 3'-flanking region of the HHEX locus, i.e., SNP rs7923837, is associated with altered glucose-stimulated insulin release. This SNP's major allele represents a risk allele for beta-cell dysfunction and, thus, might confer increased susceptibility of beta-cells toward adverse environmental factors.