The Journal of Infectious Diseases · 1997 · 24 citations · 9 references
Veterinary MedicineImmunologyInfectious DiseasesDiagnostic ParasitologyParasite ImmunologyParasitologyAntigen Detection AssaysChagas DiseaseParasitic Disease DiagnosisParasitic Disease PathogenesisProtozoal InfectionsProtozoan Host-parasite InteractionsAcute Chagas DiseaseAntibodiesBenznidazole TherapyCongenital Chagas DiseaseLongitudinal Follow-upLongitudinal Patient Follow-upTrypanosoma Cruzi InfectionTrypanosome Infections
A test based on the inhibition by antibodies of the trans-sialidase was used to analyze infection by Trypanosoma cruzi, the agent of Chagas' disease. Sera collected during the longitudinal follow-up of benznidazole-treated acutely and congenitally infected patients became negative for T. cruzi as determined by tests presently used to assess cure; however, the sera remained positive for T. cruzi by the trans-sialidase inhibition assay (TIA) up to 14 years after treatment. Therefore, TIA is a highly sensitive marker for previous T. cruzi infection.
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