Therapeutic Window for Use of Hyperbaric Oxygenation in Focal Transient Ischemia in Rats

Abstract

HBO is highly efficient in reducing infarct volume and improving neurobehavioral outcome in transient MCAO within the first 6 hours. HBO at later time points (>or=12 hours) is harmful by increasing infarct volume. In permanent MCAO, HBO failed to improve infarct volume and clinical outcome.