Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels

Abstract

Our results conform to the hypothesis that S1P inhibits acute permeability increase in association with enhanced stabilization of peripheral endothelial adhesion proteins. These results support the idea that S1P can be useful to attenuate inflammation by enhancing endothelial adhesion through activation of Rac-dependent pathways.