Germline <i>SMARCB1</i> mutation and somatic <i>NF2</i> mutations in familial multiple meningiomas

Abstract

It is concluded that, analogous to the genetic events in a subset of schwannomatosis associated schwannomas, a four-hit mechanism of tumour suppressor gene inactivation, involving SMARCB1 and NF2, might be operative in familial multiple meningiomas associated meningiomas.