Active Capture and Transport of Virus Particles Using a Biomolecular Motor‐Driven, Nanoscale Antibody Sandwich Assay

Abstract

Virus particles are captured and transported using kinesin-driven, antibody-functionalized microtubules. The functionalization was achieved through covalent crosslinking, which consequently enhanced the microtubule stability. The capture and transport of the virus particles was subsequently demonstrated in gliding motility assays in which antibody-coated microtubules functioned as capture elements, and antibody-coated microspheres served as fluorescent reporters (see Figure).