Crucial Role for Ca <sup>2+</sup> /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation - Concepedia

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Crucial Role for Ca <sup>2+</sup> /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

DOI Full Paper Access

182

Citations

42

References

2013

Year

Nazha Hamdani, Judith Krysiak, Michael M. Kreußer, Stefan Neef, Cristobal G. dos Remedios, Lars S. Maier, Marcus Krüger, Johannes Backs, Wolfgang A. Linke

Circulation Research

Abstract

CaMKII phosphorylates the titin springs at conserved serines/threonines, thereby lowering F(passive). Deranged CaMKII-dependent titin phosphorylation occurs in heart failure and contributes to altered diastolic stress.

References

	Year	Citations

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