Molecular Iodine Catalyzed Cross-Dehydrogenative Coupling Reaction between Two sp³ C–H Bonds Using Hydrogen Peroxide

Abstract

A useful method for molecular iodine catalyzed oxidative C-C bond formation between tertiary amines and a carbon nucleophile using hydrogen peroxide as the terminal oxidant is reported. This is the first report of a molecular iodine catalyzed cross-dehydrogenative coupling (CDC) reaction between two sp(3) C-H bonds.