<i>anti</i>‐Selective Asymmetric Michael Reactions of Aldehydes and Nitroolefins Catalyzed by a Primary Amine/Thiourea

Abstract

It′s finally here: Highly anti-selective Michael reactions of a functionalized aldehyde with nitroolefins have been realized using a primary amine/thiourea catalyst (see scheme; TBS=tert-butyldimethylsilyl). The reaction relies on a conformational strategy based on directing the formation of a Z-configured enamine intermediate. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.