Asymmetric Aldol Reaction Using Immobilized Proline on Mesoporous Support

Abstract

Abstract The aldol reaction of hydroxyacetone with different aldehydes using immobilized proline on a mesoporous support, assisted by heat and microwaves, has been explored. It was found that heterogenized L ‐proline on MCM‐41 catalyzed aldol reactions in both hydrophilic and hydrophobic solvents, and provided stereoselectivities in some cases complementary to the homogeneous catalyst. The heterogeneous catalysts could be reused without significant lost of stereoselectivity.