Photoactivatable Chemokines – Controlling Protein Activity by Light

Abstract

Activation by light: Caged depsipeptides are incorporated as photoresponsive elements into the backbone of the protein SDF-1α by using expressed protein ligation. The disturbed secondary structure is restored after UV treatment by an O→N acyl rearrangement, and the chemotactic potential of the protein is regained. Nvoc=6-nitroveratryloxycarbonyl.