Alcohol Dehydrogenase 3 Genotype as a Risk Factor for Upper Aerodigestive Tract Cancers

Abstract

These results suggest that genotype AA may be a risk factor for UADT cancer, especially in individuals with low alcohol or tobacco consumption. However, further epidemiological case-control or cohort studies, preferably prospective, are needed to establish the exact role of ADH3 polymorphism and its association with the development of UADT cancers.