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Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by <i>Cryptococcus neoformans</i>

Kiem Vu, Babette B. Weksler, Ignacio A. Romero, Pierre–Olivier Couraud, Angie Gelli

Eukaryotic Cell · 2009 · 125 citations · 29 references

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Abstract

Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

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