Cytosolic phospholipase A2α gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis - Concepedia

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Cytosolic phospholipase A2α gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis

29

Citations

34

References

2010

Year

Gabriel Courties, Michel Baron, Jessy Présumey, Virginie Escriou, P. van Lent, Daniel Scherman, A. Cantagrel, Wim B. van den Berg, Florence Apparailly, J. Davignon

Arthritis & Rheumatism

Abstract

Our findings indicate that systemic RNAi-mediated cPLA(2)α gene silencing in CD11b+ cells is effective in the treatment of CIA, and Th1 suppression is one of the potential underlying mechanisms, whereas Th17 suppression is not.

References

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