Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

Frank C. Arnett, Steven M. Edworthy, D. Blöch et al. · Arthritis & Rheumatism · 1988 · 19.8K citations

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling

Karim S. Echtay · The EMBO Journal · 2003 · 589 citations · Full text

Mitophagy, Signal Transduction, Mitochondrial Function +11

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

Klaus Schulze‐Osthoff, Rudi Beyaert, Veronique Vandevoorde et al. · The EMBO Journal · 1993 · 579 citations · Full text

Redox Signaling, Gene-inductive Effects, Mitochondrial Function +10

NF- B inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

Sachiko Komazawa‐Sakon · The EMBO Journal · 2003 · 498 citations · Full text

Inflammation, Signal Transduction, Signaling Pathway +14

Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium

Gary S. Firestein, Fernando Echeverri, Michele Yeo et al. · Proceedings of the National Academy of Sciences · 1997 · 372 citations · Full text

Skin Samples, Immunology, Pathology +16