Vaccination of Small Cell Lung Cancer Patients with Polysialic Acid or<i>N</i>-Propionylated Polysialic Acid Conjugated to Keyhole Limpet Hemocyanin

Abstract

Vaccination with NP-polySA-KLH, but not polySA-KLH, resulted in a consistent high titer antibody response. We are now conducting a de-escalation dosing study with NP-polySA-KLH to better assess the immunogenicity, toxicities, and optimal dose of this vaccine. We plan to incorporate this vaccine as a component of a polyvalent vaccine with GM2, fucosylated GM1, and Globo H to target SCLC.