Catalysts for the Sonogashira Coupling—The Crownless Again Shall Be King

Abstract

Commoners displacing the nobility? The scope of the Sonogashira coupling is widening with the discovery of new catalytic systems based on a variety of metals (see picture). In particular, cheap common metals are finding a place in transformations that were previously controlled by noble metals. The developments are examined, and the advantages and disadvantages of the various catalytic systems are discussed.