Development · 1979 · 324 citations · 16 references
Life SciencesBiologyDevelopmental BiologyDevelopmental Cell BiologyEmbryogenesisEmbryologyBlastocyst DevelopmentEarly Embryonic DevelopmentEmbryonic Stem CellsEndoderm FormationMammalian EmbryologyMesoderm FormationCell Lineage AllocationEndoderm DevelopmentInner Cell Mass BiologyInner Cell Mass DifferentiationInner Cell Mass SpecificationPrimitive Endoderm DifferentiationPrimitive Endoderm FormationYolk Sac Development
Injecting dissociated 4‑5‑day inner cell mass cells into genetically dissimilar blastocysts produces two distinct patterns of chimaerism. Donor inner cell mass cells give rise to two chimaeric patterns: primitive endoderm cells contribute only to visceral yolk sac endoderm, whereas primitive ectoderm cells populate the mesoderm of the yolk sac and fetus, indicating that the fetus’s endoderm derives from primitive ectoderm and that primitive endoderm forms only extra‑embryonic endoderm.
ABSTRACT Two distinct patterns of chimaerism were found in conceptuses produced by injecting dissociated 4-5-day inner cell mass cells into genetically dissimilar blastocysts. Pattern 1 : donor cells were found in the endoderm layer of the visceral yolk sac, but not in the adjacent mesoderm layer of this organ or in the foetus itself. Pattern 2: donor cells were found in the mesoderm layer of the visceral yolk sac and/or foetus, but never in the yolk-sac endoderm as well. Primitive endoderm cells of donor inner cell masses are responsible for the first pattern and primitive ectoderm cells for the second. These results, together with those of previous studies, suggest that the entire foetus, including its endodermal components, is formed from the primitive ectoderm, and that primitive endoderm forms only extra-embryonic endoderm of the conceptus.
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Biology of the Laboratory Mouse
W. E. Heston · Journal of Heredity · 1967 · 1.4K citations
STANDARDIZED NOMENCLATURE FOR INBRED STRAINS OF MICE. THIRD LISTING.
Joan Staats · PubMed · 1964 · 480 citations