The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML

Abstract

This study reports the activation of the tumour-suppressive miR-29b by the haematopoietic key transcription factor CEBPA. Our data provide a rationale for miR-29b suppression in AML patients with loss of chromosome 7q or CEBPA deficiency.