Supramolecular Nanocircles Consisting of Streptavidin and DNA

Abstract

Thermal denaturation and subsequent rapid cooling allow novel supramolecular DNA nanocircles to be obtained in high yields from oligomeric conjugates consisting of bisbiotinylated DNA and streptavidin (see scanning force microscopy image on the left). The endogenous protein molecule within the nanocircles (picture on the right) can be conveniently used for further functionalization.