An Aldimine Cross‐Coupling for the Diastereoselective Synthesis of Unsymmetrical 1,2‐Diamines

Abstract

No protecting groups are required for the cross-coupling of N-monosubstituted α-aminonitriles with imines. Depending on the workup procedure, highly substituted unsymmetrical 1,2-diamines or 1,2-diimines can be prepared in a one-pot procedure. The diastereoselective reduction of the diimines furnishes either the syn- or the anti-configurated diamines (see scheme).