Publication | Open Access
Mass Phenotyping of Isoniazid Inactivators by Automated Determination of Acetylisoniazid in Urine
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1974
Year
EngineeringSample TreatmentMass PhenotypingBioanalysisAnalytical ChemistryToxicologyClinical ChemistryAutomated ProcedureChromatographyChemical MeasurementChemometricsPharmacologyAutomated DeterminationIsoniazid InactivatorsUrologyEnvironmental EngineeringPhysiologyManual Phenotyping MethodMedicinePigmentDrug Analysis
Abstract An automated procedure is described for phenotyping isoniazid inactivators. The method is based on the color reaction produced by N-acetylisoniazid in aqueous solution, as described by Eidus and Hamilton [Amer. Rev. Resp. Dis. 89, 587 (1964)]. Maximum sampling rate is 60 samples per hour. Results of this procedure correlated well (r = 0.987) with those of a manual phenotyping method.