Faraday Discussions · 2007 · 91 citations · 26 references
EngineeringBioengineeringBiophysicsBiosensorsSensorsVirologyHiv DiagnosisMicrofluidic DevicesMicrofluidicsMicroscale BiosensorsOptical BiosensingOptical BiosensorsMicro-optical SensorsMicrofabrication For BiosensorsMicrofluidic Optical BiosensorsMicrofluidic SensingMicrofluidic SensorsOptical DetectionVirus Detection BiosensorsWhispering Gallery Mode Biosensors
The authors present an approach for specific and rapid unlabeled detection of a virus by using a microsphere-based whispering gallery mode sensor that transduces the interaction of a whole virus with an anchored antibody. They show theoretically that this sensor can detect a single virion below the mass of HIV. A micro-fluidic device is presented that enables the discrimination between viruses of similar size and shape.
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Electrical detection of single viruses
Fernando Patolsky, Gengfeng Zheng, Oliver Hayden et al. · Proceedings of the National Academy of Sciences · 2004 · 1.3K citations · Full text
Protein detection by optical shift of a resonant microcavity
Frank Vollmer, Dieter Braun, Albert Libchaber et al. · Applied Physics Letters · 2002 · 902 citations
Shift of whispering-gallery modes in microspheres by protein adsorption
S. Arnold, M. Khoshsima, Iwao Teraoka et al. · Optics Letters · 2003 · 727 citations