Angewandte Chemie International Edition · 2006 · 254 citations · 45 references
Natural SciencesBiochemistryChemistryCatalysisOrganic ChemistryAddition ReactionsCross-coupling ReactionsHeterocycle SynthesisOrganic SynthesisAsymmetric CatalysisAsymmetric Cross-couplingAsymmetric Heterocycle SynthesisAsymmetric SynthesisChiral Product SynthesisEnantioselective Cross-couplingEnantioselective SynthesisStereoselectivity In Addition Reactions
As easy as pouring! Three CC bonds, up to three stereocenters, and ee values greater than 97 % are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS=trimethylsilyl; EWG=electron-withdrawing group). Very high enantioselectivity, control of the substituents, easy handling, and user-friendly reaction conditions are key features of this transformation.
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Enantioselective Organocatalyzed α Sulfenylation of Aldehydes
Mauro Marigo, Tobias C. Wabnitz, Doris Fielenbach et al. · Angewandte Chemie International Edition · 2005 · 956 citations · Full text
Control of four stereocentres in a triple cascade organocatalytic reaction
Dieter Enders, Matthias R. M. Hüttl, Christoph Grondal et al. · Nature · 2006 · 907 citations