Organ-Dependent Variation of Capsule Thickness in<i>Cryptococcus neoformans</i>during Experimental Murine Infection

Abstract

In studies of murine infection, the capsule thickness of Cryptococcus neoformans varied depending on the organ. The relative order of thickness was as follows: lung > brain > in vitro isolates. The differences in capsule thickness suggest that there are organ-related differences in the expression of genes responsible for capsule thickness.