Concepedia

Oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β

Han Liu, Ali Pedram, Jin Kyung Kim

Cardiovascular Research · 2010 · 91 citations · 39 references

DOIFull text

Open access

Abstract

our results demonstrate that during H/R stress, cardiomyocytes undergo p53-dependent apoptosis following phosphorylation of p53 by p38α MAPK, leading to p38β suppression. E2 protects cardiomyocytes by inhibiting p38α-p53 signalling in apoptosis.

References

39

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