Tissue‐specific up‐regulation of arginase <scp>I</scp> and <scp>II</scp> induced by p38 <scp>MAPK</scp> mediates endothelial dysfunction in type 1 diabetes mellitus

Abstract

Diabetes-induced activation of p38 MAPK causes endothelial dysfunction via selective up-regulation of arginase I expression in coronary arteries and arginase II expression in MA. Therefore, regional differences appear to exist in the arginase isoforms contributing to endothelial dysfunction in type 1 diabetes mellitus.