Ruthenium(<scp>ii</scp>)-catalyzed selective monoarylation in water and sequential functionalisations of C–H bonds

Abstract

The ruthenium(II)-phosphine catalyst RuCl2(PPh3)(p-cymene) operating water selectively leads to ortho monoarylation, with arylchlorides and heteroarylhalides, of functional arenes. Further catalytic heteroarylation with Ru(OAc)2(p-cymene) in water produces mixed bifunctional derivatives.