Prenasal thickness‐to‐nasal bone length ratio: a strong and simple second‐ and third‐trimester marker for trisomy 21

Abstract

The PT : NBL ratio is stable in the second and third trimesters of pregnancy in both normal and trisomy-21 fetuses, but all trisomy-21 fetuses in this series had a PT : NBL ratio above the 95(th) percentile. The ratio is therefore a strong marker for trisomy 21.

References

Page 1

	Year	Citations
Smith's Recognizable Patterns of Human Malformation Enid Gilbert‐Barness Archives of Pediatrics and Adolescent Medicine Developmental AnomalyGross AnatomyHuman MalformationWebsite Uses CookiesJama Pediatrics Journal	1998	2K
Observations on an Ethnic Classification of Idiots J. Langdon H. Down Journal of Mental Science EthnicityCultureSocial IdentityHumanitiesGet Access Link	1867	591
Absence of nasal bone in fetuses with trisomy 21 at 11–14 weeks of gestation: an observational study Simona Cicero, P. Curcio, Aris T. Papageorghiou, The Lancet Fetal MedicinePediatricsNasal BoneObservational StudyPrenatal Diagnosis	2001	525
Observations on an ethnic classification of idiots Down J Langdon Medical Entomology and Zoology EthnicityCultureSocial IdentityAfrican American StudiesRacial Prejudice	1866	277
The Genetic Sonogram Bryann Bromley, Ellice Lieberman, Thomas Shipp, Journal of Ultrasound in Medicine	2002	213
The functional matrix Melvin L. Moss Medical Entomology and Zoology Linear OperatorFunctional MatrixMatrix TheoryFunctional AnalysisMatrix Analysis	1962	200
Association between first trimester absence of fetal nasal bone on ultrasound and Down syndrome Lucas Otaño, Horacio Aiello, Laura Igarzábal, Prenatal Diagnosis	2002	122
Prenatal ultrasonographic diagnosis of nasal bone abnormalities in three fetuses with Down syndrome Jiri Sonek, K. H. Nicolaides American Journal of Obstetrics and Gynecology Down SyndromeDevelopmental AnomalyNasal Bone AbnormalitiesPediatricsPrenatal Diagnosis	2002	121
Fetal nasal bone length: reference range and clinical application in ultrasound screening for trisomy 21 Victor Bunduki, Rodrigo Ruano, J. Miguelez, Ultrasound in Obstetrics and Gynecology	2003	117
Nasal bone length throughout gestation: normal ranges based on 3537 fetal ultrasound measurements Jiri Sonek, David S. McKenna, Diane Webb, Ultrasound in Obstetrics and Gynecology	2003	117

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