Concepedia

Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults

Bradford C. Dickerson, Travis Stoub, Raj C. Shah, Reisa A. Sperling, Ronald Killiany, Marilyn Albert, Bradley T. Hyman, Deborah Blacker, Leyla deToledo‐Morrell

Neurology · 2011 · 374 citations · 40 references

DOIFull text

Open access

Abstract

By focusing on cortical regions known to be affected in AD dementia, subtle but reliable atrophy is identifiable in asymptomatic individuals nearly a decade before dementia, making this measure a potentially important imaging biomarker of early neurodegeneration.

References

40

Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Reisa A. Sperling, Paul Aisen, Laurel Beckett et al. · Alzheimer s & Dementia · 2011 · 7K citations · Full text

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Paulina V. Arriagada, John H. Growdon, E. Tessa Hedley‐Whyte et al. · Neurology · 1992 · 2.7K citations

Observations on the brains of demented old people

B. E. Tomlinson, G. Blessed, Martin Roth · Journal of the Neurological Sciences · 1970 · 2.1K citations

, , +8

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

Robert Katzman, Robert D. Terry, Richard DeTeresa et al. · Annals of Neurology · 1988 · 1.2K citations

Cerebrospinal Fluid tau/β-Amyloid42 Ratio as a Prediction of Cognitive Decline in Nondemented Older Adults

Anne M. Fagan, Catherine M. Roe, Chengjie Xiong et al. · Archives of Neurology · 2007 · 897 citations