Convulsive seizures and viloxazine.

Abstract

metabolism in the liver is unknown. 9The pharmacokinetics of disulfiram have not been elucidated because there are no sensitive and specific methods of determining disulfiram and its metabolites.Acute toxicity studies with disulfiram in rats have shown no signs of liver necrosis but disulfiram decreases the drug metabolising capacity of the liver.'°11This mechanism probably accounts for disulfiram's inhibition of diphenylhydantoin and warfarin metabolism.'2 13 Our findings indicate that long-term toxicity studies in animals should be performed to detect possible hepatic damage after pro- prolonged administration of disulfiram.We thank Dr K Winkler for allowing us to report observations in case 1.