Dose enhancement effect of gold nanoparticles on MAGICA polymer gel in mega voltage radiation therapy

Abstract

Polymer gel dosimeter is a promising type of radiation dosimetry method used in medical radiation therapy (1). The advantage of gel dosimetry include tissue‐like elemental composition, high spatial resolution, capability for three‐dimensional (3D) dose measurements, and possibility of preparing dosimeters of varying sizes and geometries (2). The tissue equivalent property of polymer gels also serves as a good phantom to simulate the application of medical radiation to the human body. Polymer gel dosimeters are able to directly measure the effects of contrasts agents or metallic radiation dose enhancers such as iodine and gold nanoparticles (AuNps) inside the dosimeter. In gel dosimeters, contrast agents may have uniform dispersion within the dosimeter and therefore the effects of this material can be directly quanti ied. Physical measurement of the dose enhancement produced by high Z materials with other types of radiation dosimeters, such as M. Khadem-Abolfazli1,2, M. Mahdavi1, S.R.M. Mahdavi3, Gh. Ataei2*