New England Journal of Medicine · 2014 · 1.4K citations · 15 references
Life SciencesInfectious DiseasesMicrobiologyEmerging Infectious DiseasesOutbreak InvestigationVirologyEmerging Viral DiseasesInfectious Disease DynamicsPhylogenetic EpidemiologyViral EpidemiologyViral GenomicsViral InfectionsInfection Fatality RateMolecular Epidemiology Of VirusesMolecular Epidemiology PhylogeneticsMolecular Outbreak InvestigationPathogen PhylogeneticsPhylogenetic Analysis Of PathogensTropical Infectious DiseasesViral Outbreak Investigation
In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.
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Fruit bats as reservoirs of Ebola virus
Eric M. Leroy, Brice Kumulungui, Xavier Pourrut et al. · Nature · 2005 · 1.6K citations · Full text