Bacteriophage Bionanowire as a Carrier for Both Cancer‐Targeting Peptides and Photosensitizers and its use in Selective Cancer Cell Killing by Photodynamic Therapy

Abstract

A photosensitizer, pyropheophorbid-a (PPa), is conjugated to SKBR-3 breast cancer cell-specific biological nanowire phage, to form a novel PPa-phage complex, which is further successfully used in selectively killing SKBR-3 breast cancer cells by the mechanism of photodynamic therapy (PDT).